If you’ve tried SSRIs but still struggle with depression, there’s a deeper layer that often goes overlooked. Research shows that inflammation, HPA axis dysregulation, and the gut-brain axis play major roles in mood regulation. Chronic inflammation doesn’t just lower serotonin—it redirects it, creating neurotoxic byproducts that impair brain function, energy, and motivation. This is why depression often comes with brain fog, fatigue, and low drive, not just sadness. While SSRI’s certainly have th