All it takes is 5 steps. Cologuard® is intended to screen adults 45 and older at average risk for colorectal cancer. Do not use if you have had adenomas, have inflammatory bowel disease and certain hereditary syndromes, or a personal or family history of colorectal cancer. Cologuard is not a replacement for colonoscopy in high risk patients. Cologuard performance in adults ages 45-49 is estimated based on a large clinical study of patients 50 and older. False positives and false negatives can oc