Nanopore signals and machine learning unlock new molecular analysis tool

Understanding molecular diversity is fundamental to biomedical research and diagnostics, but existing analytical tools ...
SciTech Daily

New Tool Reads DNA and RNA in a Single Cell, Unlocking Secrets of Disease

For centuries, scientists have recognized that certain illnesses can run in families, an idea that dates back to Hippocrates. Over time, researchers have become increasingly skilled at uncovering how ...
eLife

Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain

Bonnifet et al. present data on the expression and interacting partners of the transposable element L1 in the mammalian brain. The work includes important findings addressing the potential role of L1 ...
GitHub

several useful jupyter notebooks from Terra - ggplot2, bulkRNAseq, ArchR, single cell with cumulus

notebooks_2020_10_08_bulk_RNAseq_pathwayAnalysis.ipynb - a bulk RNAseq analysis tutorial I wrote using kallisto quantified data (R) youtube link for a walkthrough of ...
Business Wire

Tempus Receives U.S. FDA 510(k) Clearance for Tempus xR IVD, its RNA NGS In Vitro Diagnostic Device

CHICAGO--(BUSINESS WIRE)--Tempus AI, Inc. (NASDAQ: TEM), a technology company leading the adoption of AI to advance precision medicine and patient care, today announced it has received 510(k) ...
GitHub

manarai/byu-gbc-bio559r-course

A comprehensive tutorial for setting up and using computational tools for single-cell RNA-seq and spatial transcriptomics analysis in the BIO559R Introduction to Systems Biology course.
News Medical

New method advances RNA velocity analysis with spatial and multi batch integration

Essentially all cells in an organism's body have the same genetic blueprint, or genome, but the set of genes that are actively expressed at any given time in a cell determines what type of cell it ...
IEEE

kmmDE: a Non-parametric Method for Differential Expression Analysis of Time-course RNA-seq Data Using Maximum Mean Discrepancy

Abstract: Accurately identifying differentially expressed genes from time-course RNA-Seq data is essential for understanding the dynamics of transcriptome changes during biological processes. Although ...
gut.bmj

Single-cell multimodal analysis reveals the dynamic immunopathogenesis of HBV-ACLF progression

3 Transplantation Center, The Third Xiangya Hospital, Central South University, Changsha, China Background Acute-on-chronic liver failure (ACLF) is a life-threatening syndrome involving dysfunction of ...
IEEE

LYNX-RNA: A Scalable Nextflow Workflow for RNA-Seq Analysis with Integrated Large Language Models for Comprehensive Result Interpretation

Abstract: RNA sequencing has become an essential technique in the life sciences, providing a comprehensive methodology. RNA sequencing has become an essential method in the life sciences, providing a ...
Frontiers

Integrating single-cell RNA-seq, bulk RNA-seq and network pharmacology reveals protective effect of salidroside in peritoneal dialysis-associated peritoneal fibrosis

Salidroside (2- (4-Hydroxyphenyl) ethyl β-D-glucopyranoside, SAL) is a bioactive compound present in Rhodiola rosea L., exhibiting diverse pharmacological properties such as anti-inflammatory and anti ...