Familiar matchups abound on the NFL Week 10 schedule as there are half a dozen divisional games you can make Week 10 NFL picks on. The highlight of that slate is Rams vs. 49ers, which has L.A. as 3.5-point road favorites,

Jacoby Brissett will start for the Cardinals in place of Kyler Murray against the Seattle Seahawks in Week 10 — and perhaps much longer.

Arizona Cardinals quarterback Jacoby Brissett (7) passes against the Dallas Cowboys in the first half at AT&T Stadium on Nov. 3, 2025.