Genomic identification method provides diagnoses for 145 families with rare conditions

A new genomic method has enabled multiple people with rare conditions to receive diagnoses that were previously unattainable ...
Nature

A simple method based on Sanger sequencing and MS Word wildcard searching to identify Cas9-induced frameshift mutations

Recent advances in targeted genome editing have enabled sequence-specific modifications in eukaryotic genomes. As it can be easily reprogrammed, the clustered regularly interspaced short palindromic ...
Nature

Frederick Sanger: Method Man, Problem Solver

Method man. The brilliance of Frederick Sanger's work lies not in what he discovered but in how he discovered it. A skilled experimentalist, he developed novel techniques for sequencing proteins and ...
News Medical

Challenges with Sanger Sequencing

Sanger sequencing is a method of sequencing DNA developed by Frederick Sanger in 1977. In Sanger sequencing, chain-terminating dideoxynucleotides are incorporated into the growing DNA chain at random ...