WHEN nerve impulses bring about the development of tension in a muscle, depolarization of the muscle fibre membranes can be observed. The question arises: Is this depolarization directly responsible ...
IT is generally believed that the process which initiates contraction in striated muscle is the depolarization of the excitable membrane of the muscle fibre, although the mechanism by which membrane ...
Membrane depolarization activates voltage-dependent Ca²⁺ channels (VDCCs) inducing Ca²⁺ release via ryanodine receptors (RyRs), which is obligatory for skeletal and cardiac muscle contraction and ...
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...
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