Pancreas development in pigs resembles humans much more closely than does the established mouse model. An international team ...

DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a number of ...

Regulators are supposed to abide by society's “bargain” with them: Civil servants are granted lifetime tenure and protected from political pressure and retaliation, and in return, they are supposed to ...

When six infants around the world were diagnosed with an odd trio of symptoms (diabetes, epilepsy, and abnormally small heads ...

We are now in the second great wave of the genetic revolution, not defined by reading the human code of life, but by rewriting it.

The numbers of the principal regulatory elements present in insulin promoters are listed. Given the complexity and uncertainty of predicting the transcriptional outcome of mutations within regulatory ...