DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a number of ...

Regulators are supposed to abide by society's “bargain” with them: Civil servants are granted lifetime tenure and protected from political pressure and retaliation, and in return, they are supposed to ...

We are now in the second great wave of the genetic revolution, not defined by reading the human code of life, but by rewriting it.

A man with type 1 diabetes has become the first patient to produce his own insulin after receiving genetically engineered cell transplants, without needing drugs to prevent rejection. The case, ...

People with Type 1 diabetes lose insulin-producing beta cells due to an autoimmune reaction, forcing lifelong dependence on ...

When six infants around the world were diagnosed with an odd trio of symptoms (diabetes, epilepsy, and abnormally small heads ...

The numbers of the principal regulatory elements present in insulin promoters are listed. Given the complexity and uncertainty of predicting the transcriptional outcome of mutations within regulatory ...