Genome editing is a powerful biotechnology tool that allows scientists to make precise changes to an organism's DNA. It involves the use of specialized enzymes, known as engineered nucleases or ...

The Human Genome Project changed everything. A map of the entire human sequence of DNA was the starting point for an enormous number of discoveries, from disease genes to how humans evolved. But DNA ...

Chloroplasts—the "light power plants" of plant cells—are increasingly the focus of synthetic biology. These organelles house ...

The prime editor is a fusion protein consisting of a catalytically impaired Cas9 nickase (Cas9n) and an engineered reverse transcriptase (RT). The Cas9n is guided by a prime editing guide RNA (pegRNA) ...

Advances in cancer immunotherapy from immune checkpoint modulation to adoptive cell transfer of tumour-infiltrating ...

A team of Chinese researchers has developed two new genome editing technologies, known collectively as Programmable Chromosome Engineering (PCE) systems. The study, published online in Cell on August ...

Genetic regulation of glucose homeostasis is central to the maintenance of human health and the prevention of metabolic disorders such as type 1 and type 2 diabetes. Recent advances in molecular ...

Over millennia, there has been a seamless continuum of technologies for genetic modification of plants, animals, and microorganisms, with progressive improvements in precision and predictability – a ...

Researchers have created a detailed map of chemical modifications to DNA that occur in the human brain from the earliest ...

It’s one small step for mice, one giant leap for mammoth-kind. Scientists endeavoring to “de-extinct” woolly mammoths through genetic modification have taken a meaningful step toward achieving their ...