DNA lesions are repaired by a cut-and-remove process called nucleotide excision repair. An in vitro biochemically defined system has been developed in which six repair factors are sufficient to excise ...

One of the biggest challenges in cancer treatment is chemoresistance: Tumors that initially respond well to chemotherapy ...

Researchers found that losing a second protein, FIGNL1, allows cancer cells missing BRCA2 to restore DNA repair by reloading ...

An elegant collaboration between researchers in the UK's two core-funded Medical Research Council Research Institutes, the Laboratory of Medical Sciences (LMS) in London and the Laboratory of ...

Bowhead whales can live over 200 years thanks to a protein that helps their cells repair DNA damage efficiently.

A gene that helped bowheads adapt to frigid Arctic waters also granted them extraordinary longevity. Could it help aging ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a ...

Ultraviolet (UV) rays from sunlight can cause DNA damage that leads to skin aging and cancer. Fortunately, our bodies have a highly efficient repair system capable of swiftly identifying and repairing ...

A new discovery offers hope for Huntington’s disease. This discovery provides hope that a DNA repair process may help slow or stop disease progression. Research has identified a critical DNA repair ...

A new study of the bizarre naked mole rat shows that the animals have evolved a DNA repair mechanism that could explain their longevity. These burrow-dwelling rats have a maximum life span of nearly ...

Following a double-strand DNA break, an enzyme called PARP1 helps hold the two strands together —like superglue— and creates a safe zone for other proteins to come repair the damage. We don’t exactly ...

This came up in a front page discussion recently, and I promised I'd do a bit of a brain dump. The motivation: people often talk about whether we're regulating the risks posed by exposure to radiation ...